Immunological Changes in Peripheral Blood of Ankylosing Spondylitis Patients during Anti-TNF-α Therapy and Their Correlations with Treatment Outcomes

Table 3

Differences in baseline clinical characteristics and immune cells between responders and nonresponders.

Items	Responders ()	Nonresponders ()	value
Gender (male, %)	18 (85.7%)	12 (85.7%)	1.00
Age (year, )			0.85
Disease duration (year, )			0.37
ESR (median[Q25-Q75])	13 (6-30)	29 (14-49)	0.035
CRP (median[Q25-Q75])	2.70 (1.19-15.72)	8.50 (6.65-33.63)	0.018
ASDAS-CRP			0.35
BASDAI			0.042
Treg			0.712
Th17			0.880
Th17/Treg			0.948
Tfh			0.816
Th1	0.18 (0.13-0.64)	0.81 (0.15-2.62)	0.200
Th2	0.43 (0.05-0.96)	0.28 (0.11-0.74)	0.749
Th1/Th2	0.52 (0.30-4.26)	2.30 (0.71-9.81)	0.178
Breg			0.041
CD3			0.729
CD4			0.976
CD8			0.849
CD4/CD8			0.878

Data were shown as .