Remote Inflammatory Preconditioning Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Inhibition of Intrinsic Apoptosis in Rats

Figure 1

RInPC attenuated LPS-induced ALI in rats. (a) Comparison of survival proportion among three groups. (b) Comparison of ALI represented by IQA between each group. (c) Comparison of wet/dry ratio between each group. (d) Comparison of lactic acid in the serum of each group. (e) Histological changes of lung tissue in each group (H&E; 200x). Control: control group; LPS: LPS injury group; RInPC: LPS+RInPC group. In comparison, the LPS injury group showed diffuse edema in alveolar spaces and interstitium of the lung, hemorrhage, severe inflammatory cell infiltration and serous exudation in the alveolar space, and thickened interlobular septa. These changes were significantly mitigated in the RInPC group. ; ; vs. control group; ^#; ^##; ^### vs. LPS group (); IQA: index of quantitative assessment.

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