The Role of Inflammasome Activation in Early HIV Infection

Figure 3

Illustration of the AIM2 inflammasome pathway activation during an HIV infection. The figure summarizes the stepwise genomic switching of the HIV upon cell entry. The AIM2 recognizes the viral dsDNA and interacts with the ASC. Activated ASC further recruits and activate the caspase 1 enzyme which triggers the process of pyroptosis (cell death).