Short-Chain Fatty Acids Promote Immunotherapy by Modulating Immune Regulatory Property in B Cells

Figure 7

Modulating PA production promotes SIT effects in mice. AR mice were treated with the procedures listed on the axis. NC: naïve control mice; AR: AR mice; SIT: AR mice treated with SIT; YPS: mice treated with YPS; Bug.d: mice treated with antibiotics to deplete intestinal bacteria; IPA: mice treated with IPA. (a, b) AR symptoms of mice, including nasal scratch times (nasal itch) (a) and sneezing (b). (c) Serum sIgE levels. (d–f) Levels of IL-4 (d), EPX (e), and MCP1 (mast cell protease-1) (f) in nasal lavage fluids (NLF). Each group consists of 6 mice. Each dot in boxplots presents data obtained from one mouse. , , and , compared with the AR group. ^#, ^##, and ^###, compared with the AR.SIT group. ^!! and ^!!!, compared with the NC group. Statistical method: ANOVA+Dunnett’s test.

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