Therapeutic Effect of Matrine on Collagen-Induced Arthritis Rats and Its Regulatory Effect on RANKL and OPG Expression

Figure 3

X-ray was used to evaluate the therapeutic effects of matrine and MTX on CIA rats: (a) healthy group; (b) CIA control group; (c) low dosage matrine group (25 mg/kg matrine group); (d) medium dosage matrine group (50 mg/kg matrine group); (e) high dosage matrine group (100 mg/kg matrine group); (f) methotrexate group (2 mg/kg MTX group). Obvious joint damage and part of the joint space disappearance could be observed in (b). In (c–f), the degree of joint damage was lower than that in (b).

(a)

(b)

(c)

(d)

(e)

(f)