Therapeutic Effect of Matrine on Collagen-Induced Arthritis Rats and Its Regulatory Effect on RANKL and OPG Expression

Figure 4

HE staining was used to evaluate the therapeutic effects of matrine and MTX on CIA rats. HE staining (magnification: 100x): (a) healthy group; (b) CIA control group; (c) low dosage matrine group (25 mg/kg matrine group); (d) medium dosage matrine group (50 mg/kg matrine group); (e) high dosage matrine group (100 mg/kg matrine group); (f) methotrexate group (2 mg/kg MTX group).

(a)

(b)

(c)

(d)

(e)

(f)