Therapeutic Effect of Matrine on Collagen-Induced Arthritis Rats and Its Regulatory Effect on RANKL and OPG Expression

Figure 6

The level of OPG and RANKL expression in the serum assessed by an ELISA. (a) The level of OPG expression in the serum; (b) the level of RANKL expression in the serum; (c) the expression of OPG/RANKL. Healthy: healthy group; control: CIA control group; 25 mg/kg: low dosage matrine group; 50 mg/kg: medium dosage matrine group; 100 mg/kg: high dosage matrine group; MTX: 2 mg/kg methotrexate group. Compared to the healthy group, ; compared to the control group, ^#, ^##, and ^###; compared to the 25 mg/kg group, ^▲▲, ^▲▲▲; compared to the 50 mg/kg group, ^□.

(a)

(b)

(c)