Therapeutic Effect of Matrine on Collagen-Induced Arthritis Rats and Its Regulatory Effect on RANKL and OPG Expression

Table 1

Changes in weight gain (%) in each of the different groups before and after treatment.

Weight gain (%)
Weight gain (%)	Healthy	Control	25 mg/kg	50 mg/kg	100 mg/kg	MTX		value
Before treatment (3 w)		^a	^a	^a	^a	^b	4.799	0.004
After treatment (9 w)		^a	^a				5.143	0.003

Healthy: healthy group; control: CIA control group; 25 mg/kg: low dosage matrine group; 50 mg/kg: medium dosage matrine group; 100 mg/kg: high dosage matrine group; MTX: 2 mg/kg methotrexate group. Compared to the healthy group, ^a; ^b.