Therapeutic Effect of Matrine on Collagen-Induced Arthritis Rats and Its Regulatory Effect on RANKL and OPG Expression

Table 2

Effects of matrine on changes in the AI score for arthritis in the CIA rats.

AI score
AI score	Healthy	Control	25 mg/kg	50 mg/kg	100 mg/kg	MTX		value
Before treatment (3 w)		^a					11.584	≤0.001
After treatment (9 w)		^a	^b	^b	^b	^b	16.276	≤0.001

Healthy: healthy group; control: CIA control group; 25 mg/kg: low dosage matrine group; 50 mg/kg: medium dosage matrine group; 100 mg/kg: high dosage matrine group; MTX: 2 mg/kg methotrexate group. Compared to the healthy group, ^a; compared to the control group, ^b.