Yangxue Jiedu Fang Ameliorates Psoriasis by Regulating Vascular Regression via Survivin/PI3K/Akt Pathway

<div>PASI scores, histomorphology, and MVD of the different groups. The effect of YXJD on IMQ-induced psoriasis-like lesions in mice (a). The PASI scores of the mice were evaluated from the 2<sup>nd</sup> day to the 5<sup>th</sup> day after model construction, and the PASI scores of each group were compared (b). The lesion samples were stained with hematoxylin and eosin (HE) (c), and the thickness was determined for each group (d). The microvessel density (MVD) of the four groups (e) was detected by immunocytochemistry. <span class="nowrap"><svg height="11.9544pt" id="M9" style="vertical-align:-3.42942pt" version="1.1" viewbox="-0.0498162 -8.52498 72.1595 11.9544" width="72.1595pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M372 352C427 368 507 407 507 502C507 548 486 592 451 616C420 638 376 650 301 650H44V622C124 616 128 610 128 527V123C128 40 122 34 36 28V0H257C336 0 402 12 453 40C512 72 548 124 548 191C548 291 471 335 372 350V352ZM213 362V558C213 591 216 602 226 608C235 614 258 618 282 618C377 618 415 558 415 490C415 406 369 362 260 362H213ZM213 328H258C380 328 450 283 450 181C450 76 377 35 296 34C231 34 213 53 213 125V328Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.761,0)"><path d="M433 39L423 65C413 59 399 54 387 54C370 54 352 69 352 114V299C352 352 342 392 307 422C285 440 255 449 225 449C168 437 102 399 75 379C56 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The difference in MVD among the 4 groups showed that MVD in the group treated with YXJD was reduced (f).</div>

Journal of Immunology Research

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Figure 2

Figure 2: Yangxue Jiedu Fang Ameliorates Psoriasis by Regulating Vascular Regression via Survivin/PI3K/Akt Pathway 