Yangxue Jiedu Fang Ameliorates Psoriasis by Regulating Vascular Regression via Survivin/PI3K/Akt Pathway

Figure 4

Protein levels of p-Akt, Akt, p-GSK3-β, GSK3-β, and β-catenin and the nuclear entry of β-catenin, as detected by Western blot, immunochemical staining, and immunofluorescence analysis YXJD inhibited the activation of the PI3K/Akt pathway. The levels of p-Akt, Akt, p-GSK3-β, GSK3-β, and β-catenin were reduced in YXJD-treated mice, as assessed by Western blotting (a–d). The nuclear entry of β-catenin (e) was decreased in the YXJD group mice compared with the model mice. Double immunofluorescence staining for CD31 (green) for vessels and β-catenin (red) in a representative skin sample from the 4 groups is shown. Nuclei were counterstained with DAPI (blue).

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