Review Article
Prognostic Role of TIGIT Expression in Patients with Solid Tumors: A Meta-Analysis
Table 2
Subgroup analysis results.
| | Random-effects model | Fixed-effects model | Heterogeneity | Analysis | | HR (95% CI) | | HR (95% CI) | | | pH |
| Cancer type | Colorectal cancer | 2 | 2.07 (0.23, 18.82) | 0.518 | 1.81 (0.94, 3.50) | 0.076 | 91.0% | 0.001 | Lung cancer | 2 | 1.29 (0.96, 1.72) | 0.094 | 1.29 (0.96, 1.72) | 0.094 | 0.0% | 0.886 | Esophagus cancer | 2 | 1.70 (1.20, 2.40) | 0.030 | 1.70 (1.20, 2.40) | 0.003 | 0.0% | 0.715 | Others | 2 | 1.86 (1.39, 2.50) | 0.001 | 1.86 (1.39, 2.50) | 0.001 | 0.0% | 0.662 | Expression position | Tumor cells | 6 | 1.78 (1.19, 2.65) | 0.005 | 1.77 (1.40, 2.22) | 0.001 | 57.7% | 0.037 | TILs | 2 | 1.44 (1.04, 2.00) | 0.027 | 1.41 (1.09, 1.83) | 0.009 | 30.2% | 0.231 | Sample size | <100 | 2 | 0.92 (0.46, 1.83) | 0.817 | 0.92 (0.47, 1.78) | 0.802 | 6.5% | 0.301 | ≥100 | 6 | 1.80 (1.36, 2.39) | 0.001 | 1.67 (1.40, 1.99) | 0.001 | 54.1% | 0.054 | Method to estimate HR | Multivariate analysis | 5 | 1.49 (1.17, 1.88) | 0.001 | 1.49 (1.24, 1.80) | 0.001 | 31.9% | 0.209 | Univariate analysis | 3 | 2.57 (1.17, 5.67) | 0.019 | 2.42 (1.54, 3.78) | 0.001 | 61.4% | 0.075 |
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