Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development

Figure 2

Effects of circ_0044516 siRNA on lung cancer cell proliferation, apoptosis, and cell-cycle. (a) Relative expression of circ_0044516 in A549 and SPCA1 cells transfected with circ_0044516 siRNA or siRNA control. (b, c) Downregulation of circ_0044516 reduced A549 and SPCA1 cell proliferation. CCK8 assays were carried out to assess cell viability. (d–f) Cell apoptosis was tested in A549 and SPCA1 cells using flow cytometric analysis. (g–i) Cell cycle distribution in A549 and SPCA1 cells using flow cytometry. Data are presented as . .

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