IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses

Figure 5

Analysis of inflammatory gene expression after rifampicin treatment in M. tuberculosis H37Rv-infected macrophages. (a, b) Increase in IFI44L expression in M. tuberculosis H37Rv-infected macrophages after 24 h of rifampicin therapy and significant increase after 72 h of rifampicin therapy in comparison with levels at 24 h. Intracellular survival of M. tuberculosis was restricted at 72 h, as shown by CFU counting assays. (c, d) CCL4, CXCL10, CXCL11, and IL18 expressions determined by qPCR and ELISA at 24, 48, and 72 h. Values are presented as levels relative to β-actin and GAPDH. ; .

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