Development and Validation of a TNF Family-Based Signature for Predicting Prognosis, Tumor Immune Characteristics, and Immunotherapy Response in Colorectal Cancer Patients

Table 2

The univariate Cox analysis of TNF family genes in the TCGA cohort.

Gene symbol	HR	Aliases	Family	HR.95L	HR.95H	value
CD27	0.9709	TNFRSF7	TNFRSF	0.8151	1.1565	0.7406
CD40	1.0949	TNFRSF5	TNFRSF	0.9181	1.3056	0.3130
CD40LG	1.0877	TNFSF5, CD154	TNFSF	0.7844	1.5083	0.6142
CD70	1.0377	TNFSF7, CD27L	TNFSF	0.8573	1.2560	0.7044
EDA	0.9661	EDA-A1, EDA-A2	TNFSF	0.7994	1.1675	0.7208
EDA2R	0.9405	TNFRSF27, XEDAR	TNFRSF	0.7224	1.2243	0.6484
EDAR	1.0668	EDA-A1R	TNFRSF	0.9437	1.2060	0.3010
FAS	0.8419	TNFRSF6, CD95	TNFRSF	0.6874	1.0311	0.0962
FASLG	0.9453	TNFSF6, CD95-L	TNFSF	0.6999	1.2766	0.7135
LTA	0.9417	TNFSF1	TNFSF	0.6381	1.3896	0.7621
LTB	1.0080	TNFSF3	TNFSF	0.8389	1.2112	0.9322
LTBR	1.4905	TNFRSF3	TNFRSF	0.9610	2.3117	0.0747
NGFR	1.1845	TNFRSF16, CD271	TNFRSF	0.9744	1.4399	0.0891
RELT	1.0834	TNFRSF19L	TNFRSF	0.7789	1.5068	0.6343
TNF	0.8812	TNFSF2, TNFA	TNFSF	0.6434	1.2069	0.4305
TNFRSF10A	0.8024	TRAILR1, CD261	TNFRSF	0.6140	1.0488	0.1071
TNFRSF10B	0.7799	TRAILR2, CD262	TNFRSF	0.5935	1.0248	0.0744
TNFRSF10C	0.7389	TRAILR3, CD263	TNFRSF	0.5563	0.9814	0.0367
TNFRSF10D	0.9766	TRAILR4, CD264	TNFRSF	0.7621	1.2514	0.8515
TNFRSF11A	0.7898	RANK, CD265	TNFRSF	0.6530	0.9554	0.0151
TNFRSF11B	0.9560	OPG	TNFRSF	0.8222	1.1115	0.5582
TNFRSF12A	1.0208	FN14, TWEAKR, CD266	TNFRSF	0.8196	1.2715	0.8542
TNFRSF13B	0.9264	TACI, TNFRSF14B, CD267	TNFRSF	0.5875	1.4606	0.7420
TNFRSF13C	1.1481	BAFFR, CD268	TNFRSF	0.8683	1.5180	0.3326
TNFRSF14	1.3445	LIGHTR, HVEM, CD270	TNFRSF	0.9390	1.9252	0.1061
TNFRSF17	0.8806	BCMA, TNFRSF13A, CD269	TNFRSF	0.7463	1.0390	0.1318
TNFRSF18	1.0049	GITR, AITR, CD357	TNFRSF	0.8154	1.2386	0.9631
TNFRSF19	1.1917	TROY, TAJ	TNFRSF	1.0162	1.3976	0.0309
TNFRSF1A	1.1784	TNFR1, CD120A	TNFRSF	0.7865	1.7654	0.4262
TNFRSF1B	0.8724	TNFR2, CD120B	TNFRSF	0.6804	1.1186	0.2819
TNFRSF21	1.1121	DR6, CD358	TNFRSF	0.7778	1.5902	0.5602
TNFRSF25	1.3221	DR3, TNFRSF12	TNFRSF	1.0482	1.6675	0.0184
TNFRSF4	1.0445	OX40, CD134	TNFRSF	0.8318	1.3116	0.7078
TNFRSF6B	NA	DCR3	TNFRSF	NA	NA	NA
TNFRSF8	0.9705	CD30	TNFRSF	0.6332	1.4876	0.8908
TNFRSF9	0.8403	4-1BB, CD137, ILA	TNFRSF	0.6078	1.1616	0.2922
TNFSF10	0.9383	TRAIL, CD253	TNFSF	0.7388	1.1917	0.6018
TNFSF11	0.8209	RANKL, CD254	TNFSF	0.6601	1.0207	0.0758
TNFSF12	1.1672	TWEAK	TNFSF	0.9247	1.4732	0.1931
TNFSF13	1.0137	APRIL, CD256	TNFSF	0.8102	1.2683	0.9054
TNFSF13B	1.0583	BAFF, CD257	TNFSF	0.8784	1.2750	0.5510
TNFSF14	0.8514	LIGHT, HVEML, CD258	TNFSF	0.5787	1.2526	0.4141
TNFSF15	0.9451	TL1A	TNFSF	0.7111	1.2563	0.6976
TNFSF18	0.8249	GITRL	TNFSF	0.5191	1.3108	0.4152
TNFSF4	0.9764	OX40L, CD134L, CD252	TNFSF	0.7877	1.2104	0.8278
TNFSF8	1.1121	CD30L, CD153	TNFSF	0.7984	1.5490	0.5299
TNFSF9	0.9408	4-1BB-L, CD137L	TNFSF	0.8274	1.0698	0.3521