Serum CD4 Is Associated with the Infiltration of CD4+T Cells in the Tumor Microenvironment of Gastric Cancer
Table 2
Associations between clinicopathologic variables and systemic inflammatory markers in GC.
Variables
CD4
CD8
CD19
Low ()
High ()
Low ()
High ()
Low ()
High ()
Sex
0.559
0.858
0.137
Male
69
97
24
142
53
113
Female
24
28
7
45
11
41
Age (years)
0.024
0.110
0.020
<70
72
111
23
160
48
135
≥70
21
14
8
27
16
19
Borrmann classificationa
0.041
0.280
0.246
I
11
27
9
29
12
26
II
15
30
5
40
14
31
III
47
42
10
79
30
59
IV
20
26
7
39
8
38
Vascular invasion
0.071
0.839
0.960
Absent
49
81
19
111
38
92
Present
44
44
12
76
26
62
Neural invasion
0.091
0.592
0.742
Absent
29
53
13
69
23
59
Present
64
72
18
118
41
95
TNM stageb
0.174
0.071
0.941
I
11
28
4
35
13
26
II
25
33
10
48
16
42
III
49
58
12
95
31
76
IV
8
6
5
9
4
10
Lymph node ratio (involved/examined lymph nodes)
0.026
0.873
0.147
0
23
45
9
59
22
46
>0 to ≤0.3
36
49
14
71
18
67
>0.3 to ≤0.6
19
25
5
39
15
29
>0.6
15
6
3
18
9
12
WHO classification
0.895
0.127
0.827
Well to moderately differentiated
43
53
17
79
28
68
Poorly differentiated
24
31
3
52
17
38
Signet ring cell
21
33
10
44
14
40
Mucinous
5
8
1
12
5
8
Tumor location
0.778
0.071
0.204
Lower third
7
11
2
16
37
106
Middle third
18
23
2
39
14
27
Upper third
63
80
22
121
5
13
Entire stomach
5
11
5
11
8
8
aBorrmann type I: polyp type; Borrmann type II: local infiltration type; Borrmann type III: ulcer type; Borrmann type IV: diffusely infiltrative type. bBased on the 8th edition of the AJCC Cancer Staging Manual of the American Joint Committee on Cancer.