Serum CD4 Is Associated with the Infiltration of CD4⁺T Cells in the Tumor Microenvironment of Gastric Cancer

Table 2

Associations between clinicopathologic variables and systemic inflammatory markers in GC.

Variables	CD4			CD8			CD19
	Low ()	High ()		Low ()	High ()		Low ()	High ()
Sex			0.559			0.858			0.137
Male	69	97		24	142		53	113
Female	24	28		7	45		11	41
Age (years)			0.024			0.110			0.020
<70	72	111		23	160		48	135
≥70	21	14		8	27		16	19
Borrmann classification^a			0.041			0.280			0.246
I	11	27		9	29		12	26
II	15	30		5	40		14	31
III	47	42		10	79		30	59
IV	20	26		7	39		8	38
Vascular invasion			0.071			0.839			0.960
Absent	49	81		19	111		38	92
Present	44	44		12	76		26	62
Neural invasion			0.091			0.592			0.742
Absent	29	53		13	69		23	59
Present	64	72		18	118		41	95
TNM stage^b			0.174			0.071			0.941
I	11	28		4	35		13	26
II	25	33		10	48		16	42
III	49	58		12	95		31	76
IV	8	6		5	9		4	10
Lymph node ratio (involved/examined lymph nodes)			0.026			0.873			0.147
0	23	45		9	59		22	46
>0 to ≤0.3	36	49		14	71		18	67
>0.3 to ≤0.6	19	25		5	39		15	29
>0.6	15	6		3	18		9	12
WHO classification			0.895			0.127			0.827
Well to moderately differentiated	43	53		17	79		28	68
Poorly differentiated	24	31		3	52		17	38
Signet ring cell	21	33		10	44		14	40
Mucinous	5	8		1	12		5	8
Tumor location			0.778			0.071			0.204
Lower third	7	11		2	16		37	106
Middle third	18	23		2	39		14	27
Upper third	63	80		22	121		5	13
Entire stomach	5	11		5	11		8	8

^aBorrmann type I: polyp type; Borrmann type II: local infiltration type; Borrmann type III: ulcer type; Borrmann type IV: diffusely infiltrative type. ^bBased on the 8th edition of the AJCC Cancer Staging Manual of the American Joint Committee on Cancer.