Serum CD4 Is Associated with the Infiltration of CD4+T Cells in the Tumor Microenvironment of Gastric Cancer
Table 3
Univariate and multivariate analyses of independent risk factors for death of patients with GC.
Variables
Univariate analysisc
Multivariate analysisd
HR
95% CI
HR
95% CI
Univariate and multivariate analyses with the circulating CD4+T cells
Sex
0.285
—
—
—
Male
1
Female
0.792
0.517-1.215
Age (years)
0.159
—
—
—
<70
1
≥70
1.378
0.882-2.154
Tumor location
0.007
0.662
U
1
1
M
1.083
0.522-2.246
0.768
0.360-1.637
L
0.837
0.432-1.622
0.751
0.383-1.473
LMU
2.306
1.022-5.204
1.033
0.436-2.451
Borrmann typea
<0.001
0.056
I
1
1
II
1.009
0.477-2.133
0.504
0.229-1.107
III
2.711
1.454-5.055
1.042
0.524-2.072
IV
2.947
1.531-5.673
1.161
0.572-2.358
WHO classification
0.083
Well to moderately differentiated
1
1
Poorly differentiated
1.491
0.950-2.338
1.784
1.050-3030
Signet ring cell
1.584
1.017-2.468
1.565
0.961-2.551
Mucinous
2.003
1.006-3.989
0.975
0.428-2.220
TNM stageb
<0.001
<0.001
I
1
1
II
7.116
2.152-23.526
6.457
1.883-22.135
III
14.823
4.678-46.969
12.624
3.636-43.828
III
26.953
7.479-97.131
22.266
5.663-87.553
Vascular infiltration
<0.001
0.750
Absent
1
1
Present
2.065
1.446-2.947
1.069
0.709-1.611
Neural invasion
<0.001
0.811
Absent
1
1
Present
2.330
1.534-3.538
0.943
0.584-1.524
Serum CD4
0.002
0.008
Low
1
1
High
1.814
1.255-2.622
0.597
0.409-0.873
Univariate and multivariate analyses with the circulating CD8+T cells
Sex
0.285
—
—
—
Male
1
Female
0.792
0.517-1.215
Age (years)
0.159
—
—
—
<70
1
≥70
1.378
0.882-2.154
Tumor location
0.007
0.765
U
1
1
M
1.083
0.522-2.246
0.788
0.369-1.682
L
0.837
0.432-1.622
0.792
0.403-1.555
LMU
2.306
1.022-5.204
1.036
0.435-2.466
Borrmann typea
<0.001
0.014
I
1
1
II
1.009
0.477-2.133
0.502
0.229-1.104
III
2.711
1.454-5.055
1.160
0.589-2.284
IV
2.947
1.531-5.673
1.356
0.677-2.715
WHO classification
0.083
0.669
Well to moderately differentiated
1
1
Poorly differentiated
1.491
0.950-2.338
1.313
0.784-2.197
Signet ring cell
1.584
1.017-2.468
1.253
0.764-2.056
Mucinous
2.003
1.006-3.989
1.438
0.668-3.093
TNM stageb
<0.001
<0.001
I
1
1
II
7.116
2.152-23.526
6.551
1.909-22.487
III
14.823
4.678-46.969
13.398
3.847-46.659
III
26.953
7.479-97.131
23.754
6.022-93.704
Vascular infiltration
<0.001
0.672
Absent
1
1
Present
2.065
1.446-2.947
1.094
0.723-1.654
Neural invasion
<0.001
0.739
Absent
1
1
Present
2.330
1.534-3.538
0.922
0.571-1.487
Serum CD8
0.667
—
—
—
Low
1
High
0.896
0.543-1.477
Univariate and multivariate analyses with the circulating CD19+B cells
Sex
0.285
—
—
—
Male
1
Female
0.792
0.517-1.215
Age (years)
0.159
—
—
—
<70
1
≥70
1.378
0.882-2.154
Tumor location
0.007
0.832
U
1
1
M
1.083
0.522-2.246
0.722
0.340-1.534
L
0.837
0.432-1.622
0.734
0.373-1.443
LMU
2.306
1.022-5.204
0.738
0.302-1.803
Borrmann typea
<0.001
0.006
I
1
1
II
1.009
0.477-2.133
0.468
0.212-1.032
III
2.711
1.454-5.055
1.062
0.539-2.092
IV
2.947
1.531-5.673
1.458
0.727-2.920
WHO classification
0.083
Well to moderately differentiated
1
Poorly differentiated
1.491
0.950-2.338
Signet ring cell
1.584
1.017-2.468
Mucinous
2.003
1.006-3.989
TNM stageb
<0.001
<0.001
I
1
1
II
7.116
2.152-23.526
6.824
1.997-23.318
III
14.823
4.678-46.969
14.851
4.264-51.726
III
26.953
7.479-97.131
30.290
7.609-120.574
Vascular infiltration
<0.001
0.740
Absent
1
1
Present
2.065
1.446-2.947
.073
0.707-1.630
Neural invasion
<0.001
0.700
Absent
1
1
Present
2.330
1.534-3.538
0.910
0.565-1.468
Serum CD19
0.023
0.004
Low
1
1
High
0.653
0.451-0.944
0.548
0.365-0.821
aBorrmann type I: polyp type; Borrmann type II: local infiltration type; Borrmann type III: ulcer type; Borrmann type IV: diffusely infiltrative type. bBased on the 8th edition of the AJCC Cancer Staging Manual of the American Joint Committee on Cancer. cLog rank test was used for univariate analysis. dCox regression model was used for multivariate analysis.
