Clinicopathological and Prognostic Significance of CD47 Expression in Lung Neuroendocrine Tumors

Table 1

General characteristic of the entire population according to CD47 expression (positive vs. negative).

Characteristics	Categories	ALL % ()	CD47- % ()	CD47+ % ()	value
		()	()	()
Gender	Female	59 (30)	66.7 (20)	33.3 (10)
	Male	41 (21)	81 (17)	19 (4)	0.346
	Median (±SD)
Age	<60 years	54.9 (28)	82.1 (23)	17.9 (5)
	≥60 years	45.1 (23)	60.9 (14)	39.1 (9)	0.120
Smoking history	Nonsmoker	39.2 (20)	27.5 (14)	30 (6)
	Smoker	60.8 (31)	77.5 (23)	25.8 (8)	0.758
ECOG PS	0-1	78.4 (40)	70 (28)	30 (12)
	2+	21.6 (11)	81.8 (9)	18.2 (2)	0.705
Disease stage	IIIB	27.5 (14)	71.4 (10)	28.6 (4)
	IV	72.5 (37)	73 (27)	27 (10)	1.0
Histological grade	Carcinoid	15.7 (8)	75 (6)	25 (2)
	Atypical	7.8 (4)	75 (3)	25 (1)
	Large cells	19.6 (10)	60 (6)	40 (4)
	Small cells	56.9 (29)	75.9 (22)	24.1 (7)	0.804
Lung metastases	Absent	88.2 (45)	73.3 (33)	26.7 (12)
	Present	11.8 (6)	66.7 (4)	33.3 (2)	0.661
Bone metastases	Absent	84.3 (43)	72.1 (31)	27.9 (12)
	Present	15.7 (8)	75 (6)	25 (2)	1.0
Pleural effusion	Absent	78.4 (40)	67.5 (27)	32.5 (13)
	Present	21.6 (11)	90.9 (10)	9.1 (1)	0.251
CNS metastases	Absent	72.5 (37)	73 (27)	27 (10)
	Present	27.5 (14)	71.4 (10)	28.6 (4)	1.0
Liver metastases	Absent	80.4 (41)	68.3 (28)	31.7 (13)
	Present	19.6 (10)	90 (9)	10 (1)	0.250
Adrenal metastases	Absent	88.2 (45)	73.3 (33)	26.7 (12)
	Present	11.8 (6)	66.7 (4)	33.3 (2)	0.661
CD47	Positive	72.5 (37)			0.771
	Negative	27.5 (14)
Ki-67	5-19%	17.6 (9)	77.8 (7)	22.2 (2)
	20-39%	5.9 (3)	66.7 (2)	33.3 (1)
	40-80%	19.6 (10)	60 (6)	40 (4)
	50-100%	56.9 (29)	75.9 (22)	24.1 (7)