Research Article
Clinicopathological and Prognostic Significance of CD47 Expression in Lung Neuroendocrine Tumors
Table 2
Univariate and multivariate analysis for factors associated with PFS.
| | | Progression-free survival | Median, 95% CI | | HR (95% CI) | |
| Gender | Female | 18.2 (0-43.1) | | | | Male | 7.7 (4.9-10.5) | 0.067 | | | Age | <60 years | 10.3 (5.9-14.7) | | | | ≥60 years | 18.8 (0.4-37.2) | 0.415 | | | Tobacco smokers | Nonsmoker | 27.3 (3.0-51.7) | | | | Smoker | 6.2 (3.8-8.6) | 0.163 | | | ECOG PS | 0-1 | 10.3 (0-20.9) | | | | 2+ | 4.6 (N/R) | 0.393 | | | Disease stage | IIIB | N/R (N/R) | | | | IV | 6.5 (4.3-8.6) | 0.002 | 1.6 (0.7-4.0) | 0.237 | Histological subtype | Carcinoid | NA | | | | Atypical | | | | | Large cell | | | | | Small cell | | | | | Lung metastases | Absent | 10.3 (0.2-20.4) | | | | Present | 3.4 (1.1-5.7) | 0.349 | | | Bone metastases | Absent | 7.8 (1.2-14.4) | | | | Present | 10.3 (3.6-17.0) | 0.579 | | | Pleural effusion | Absent | 16.9 (4.1-29.7) | | | | Present | 3.4 (0.0-6.8) | <0.001 | 9.4 (2.3-38.5) | 0.02 | CNS metastases | Absent | 16.9 (6.8-27.1) | | | | Present | 6.5 (4.3-8.6) | 0.033 | 5.2 (1.4-19.3) | 0.013 | Liver metastases | Absent | 15.7 (0.0-32.3) | | | | Present | 6.0 (0.0-11.9) | 0.018 | 3.1 (1.0-9.6) | 0.047 | Adrenal metastases | Absent | 10.3 (3.4-17.2) | | | | Present | 7.8 (7.6-8.1) | 0.593 | | | CD47 | Negative | 7.8 (4.9-10.7) | | | | Positive | 45.7 (0.0-115.3) | 0.059 | 0.7 (0.2-2.5) | 0.620 |
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