Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity

Figure 1

Overview of subpopulations, important receptors, and cytokines produced by γδ T cells. γδ T cells express some receptors that are essential for the tumor recognition and destruction, which gives a certain advantage when compared to other conventional T lymphocyte populations, either due to MHC independence or due to the high expression of the receptors mentioned in the image. The antileukemic recognition repertoire includes several molecules, such as NKG2D, NCRs, FasL, CD16, DNAM-1, and the TCR γδ itself.