Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity

Figure 3

Overview of subpopulations, important receptors, and cytokines produced by MAIT cells. MAIT cells develop in the thymus, where they acquire a semi-invariant TCR, restricted to MR1. In humans, they can be categorized into five subsets based on the expression of the CD4 and CD8 coreceptors, with CD4^- CD8αα⁺ or CD4^- CD8αβ⁺ being the most abundant, collectively corresponding to approximately 80% of MAIT cells. They produce a repertoire of Th1 and Th17 cytokines (IFN-γ, TNF, IL-2, IL-17A, and IL-22), in addition to perforins and granzymes B, and express various cytokine, chemokine, and homing molecules.