Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity

Table 1

The table indicates some functions triggered by unconventional T cells in the immune response against the tumor.

Subsets	Role played in the immune response against cancer cells	Reference
γδ T cells	Mediate tumor regression by recognizing MIC-A/MIC-B and ULBPs through TCR and NKG2D	[34, 35, 51, 52, 90]
	Antitumor potential increased by expression of NCRs	[36]
	Positive regulation of pAgs in LCs mediates the immune response through γδ TCR	[40, 41, 72]
	BTN3A/BTN2A1 increases the antitumor functions of γδ T cells in blood	[72–74]
	Mediate tumor regression by recognizing PVR and nectin-2 through TCR and DNAM-1	[41]
	BTN3A-expressing LCs are recognized and destroyed by γδ T cells in blood through TCR	[69]
	Induce the maturation of DCs, which consequently enhance their activity against LCs	[29, 30]
NKT cells	Mediates tumor regression by recognizing CD1d^+ LCs through TCR	[133]
	Induces direct destruction of tumor cells through granulysin	[124, 125]
	Induces direct tumor lysis through FasL	[111]
	They act in the immunovigilance during the initial phase of the neoplastic process	[131–134]
MAIT cells	Induces direct cytotoxicity mediated by granzyme B and perforin in cancer cells that express MR1	[162, 175]