Identification of SHMT2 as a Potential Prognostic Biomarker and Correlating with Immune Infiltrates in Lung Adenocarcinoma

Figure 3

Upregulated gene expression was associated with an immunologic process and was validated by GSEA of GO gene sets analysis of high expression of SHMT2 in GSE21933, GSE31210, and GSE116959. (a) Leukocyte activation involved in inflammatory response, (b) macrophage activation, (c) response to interleukin 6, (d) adaptive immune response, (e) alpha beta T cell activation, (f) alpha beta T cell differentiation, (g) B cell receptor signaling pathway, (h) negative regulation of T cell mediated immunity, and (i) positive regulation of interleukin 2 production.

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