Low Distribution of TIM-3⁺ Cytotoxic Tumor-Infiltrating Lymphocytes Predicts Poor Outcomes in Gastrointestinal Stromal Tumors

Table 2

Correlation of TIM-3⁺, Gal-9⁺, CD8⁺, and CD56⁺ TIL densities with clinicopathological characteristics.

Characteristics	TIM-3^+		value	Gal-9^+		value	CD8^+		value	CD56^+		value
	Low	High		Low	High		Low	High		Low	High
Age (years)			0.441			0.873			0.035			0.283
≤59	90	72		76	86		97	65		93	69
>59	70	67		63	74		98	39		87	50
Gender			0.668			0.508			0.465			0.827
Male	88	73		72	89		108	53		96	65
Female	72	66		67	71		87	51		84	54
Modified NIH criteria			<0.0001			<0.0001			<0.0001			0.001
Low risk	47	70		71	46		60	57		55	62
Intermediate risk	24	23		23	24		35	12		31	16
High risk	89	46		45	90		100	35		94	41
Tumor size			<0.0001			0.009			0.004			0.004
≤5 cm	56	77		73	60		75	58		68	65
>5 cm	104	62		66	100		120	46		112	54
Tumor site			0.419			0.088			<0.0001			0.153
Stomach	93	74		76	91		124	43		108	59
Small bowel	45	51		52	44		42	54		50	46
Colon	4	3		3	4		5	2		3	4
Others	18	11		8	21		24	5		19	10
Mitoses per 50 HPFs			<0.0001			0.035			0.001			0.004
≤5	92	106		102	96		115	83		108	90
5-10	24	20		14	30		32	12		27	17
≥10	44	13		23	34		48	9		45	12
Tumor bleeding			0.679			0.913			0.857			0.339
Yes	27	26		25	28		34	19		35	18
No	133	113		114	132		161	85		145	101
Ki67 classification			0.099			0.030			0.357			0.275
I	101	103		99	105		128	76		117	87
II	25	18		24	19		29	14		27	16
III	34	18		16	36		38	14		36	16
Recurrence state			0.038			<0.0001			<0.0001			0.078
Yes	41	22		16	47		55	8		44	19
No	119	117		123	113		140	96		136	100
Local invasion			0.080			0.041			0.028			0.016
Yes	37	21		20	38		45	13		43	15
No	123	118		119	122		150	91		137	104

Abbreviations: HPF, high power field. Note: The values in bold type are those with statistical significance ().