p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway

Figure 5

p75NTR/proBDNF overexpression modulates the recruitment of adaptive and innate immune cells. (a) Representative gating (FlowJo) and quantitation of CD45⁺CD11b⁺F4/80⁺ cells (macrophages) and CD45⁺CD11b⁺Ly6G⁺ cells (neutrophils) in normal skin, p75NTR BCC, and p75NTR/proBDNF BCC. (b–d) Representative gating (FlowJo) and quantitation of CD45⁺CD3⁺CD8⁺ cells (CD8 T cells) in normal skin, p75NTR BCC, and p75NTR/proBDNF BCC. (e) In human samples, quantitation of cytokines and chemokines of M1 and M2 (macrophages) in normal skin and p75NTR/proBDNF BCC. In a syngeneic mouse model of BCC, quantitation of cytokines and chemokines of M1and M2 (macrophages) in normal skin and p75NTR/proBDNF BCC.

(a)

(b)

(c)

(d)

(e)