Leukocytes from Patients with Drug-Sensitive and Multidrug-Resistant Tuberculosis Exhibit Distinctive Profiles of Chemokine Receptor Expression and Migration Capacity

Figure 4

Kinetics of CD4+ T cell subpopulations in MDR-TB patients. Representative zebra plots showing the strategy of analysis used to enumerate naïve (CD45RA+CCR7+), central memory (CM, CD45RA-CCR7+), effector memory (EM, CD45RA-CCR7-), and TEMRA (CD45RA+CCR7-) CD3+CD4+ T cells in peripheral blood mononuclear cells (PBMCs) from multidrug-resistant (MDR-TB) and drug-sensitive (DS-TB) patients (a and c, respectively). (b) Frequency of CD3+CD4+ T cell subpopulations in MDR-TB patients (HD: , MDR-TB: basal, 1, and 3 moTBt , 8 moTBt , and 16 moTBt ). (d) Frequency of CD3+CD4+ T cell subpopulations in DS-TB patients (HD , DS-TB: basal and 1 moTBt , and 6 moTBt n). Bar graphs depict . Differences between patient groups and HD at each time point were analyzed using multiple Student’s -test corrected for multiple comparisons using the Sidak–Bonferroni method. , , , and . moTBt: months of antituberculosis treatment.

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