Increased TNF-α Initiates Cytoplasmic Vacuolization in Whole Blood Coculture with Dengue Virus

Figure 5

Abnormal production of TNF-α caused by DENV infection correlates with the cytopathological effects 24 h postincubation. (a) Following DENV () coculture in 100 μl of WB ex vivo for 24 h, TNF-α production was measured in the plasma by ELISA. The quantitative data are depicted as the obtained from five cases. , compared to the mock group. (b) Furthermore, correlation analysis showed the strength of the relationship between TNF-α production and the induction of vacuolization, which is expressed numerically based on the and values.

(a)

(b)