Current and Future Perspectives of PD-1/PDL-1 Blockade in Cancer Immunotherapy

Figure 1

Mechanism of action of PD-1/L1 checkpoint blockade. PD-1: programmed cell death protein-1; TCR: T cell receptor; PDL-1/2: programmed death-ligand 1/2; APC: antigen presenting cell; MHC1: major histocompatibility complex 1; CTLA4: cytotoxic T-lymphocyte-associated protein 4.