Research Article
Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation
Table 2
The frequency of the 10 most frequent HLA-A, -C, -B, and -DRB1 alleles in Zagreb and their respective frequencies in five different Croatian regions.
| | ZG () | DA () | I&P () | CC () | NC () | EC () | | AF | AF | AF | AF | AF | AF |
| HLA-A | 02:01 | 0.2946 | 0.2830 | 0.2688 | 0.2933 | 0.3146 | 0.2818 | 01:01 | 0.1289 | 0.1407 | 0.1400 | 0.1166 | 0.1168 | 0.1396 | 03:01 | 0.1176 | 0.1005 | 0.1081 | 0.1156 | 0.1096 | 0.1018 | 24:02 | 0.1149 | 0.1106 | 0.1243 | 0.1185 | 0.1149 | 0.1119 | 11:01 | 0.0660 | 0.0839 | 0.0723 | 0.0622 | 0.0758 | 0.0765 | 26:01 | 0.0496 | 0.0460 | 0.0468 | 0.0593 | 0.0419 | 0.0519 | 32:01 | 0.0436 | 0.0473 | 0.0393 | 0.0397 | 0.0429 | 0.0418 | 68:01 | 0.0411 | 0.0437 | 0.0486 | 0.0387 | 0.0367 | 0.0397 | 25:01 | 0.0292 | 0.0274 | 0.0278 | 0.0289 | 0.0253 | 0.0312 | 23:01 | 0.0252 | 0.0186 | 0.0214 | 0.0294 | 0.0167 | 0.0237 | ∑ | 0.9107 | 0.9017 | 0.8974 | 0.9022 | 0.8952 | 0.8999 |
| HLA-C | 04:01 | 0.1572 | 0.1354 | 0.1457 | 0.1455 | 0.1668 | 0.1428 | 07:01 | 0.1488 | 0.1697 | 0.1688 | 0.1410 | 0.1506 | 0.1630 | 12:03 | 0.1161 | 0.1377 | 0.1202 | 0.1219 | 0.0848 | 0.1244 | 02:02 | 0.0931 | 0.0875 | 0.0786 | 0.1024 | 0.0958 | 0.0916 | 06:02 | 0.0835 | 0.0809 | 0.0983 | 0.0931 | 0.0720 | 0.0924 | 07:02 | 0.0803 | 0.0702 | 0.0809 | 0.0769 | 0.0877 | 0.0717 | 01:02 | 0.0452 | 0.0597 | 0.0486 | 0.0480 | 0.0405 | 0.0461 | 03:03 | 0.0416 | 0.0333 | 0.0382 | 0.0407 | 0.0453 | 0.0418 | 05:01 | 0.0413 | 0.0415 | 0.0347 | 0.0382 | 0.0400 | 0.0424 | 15:02 | 0.0373 | 0.0415 | 0.0457 | 0.0358 | 0.0329 | 0.0330 | ∑ | 0.8444 | 0.8574 | 0.8597 | 0.8435 | 0.8164 | 0.8492 |
| HLA-B | 51:01 | 0.1045 | 0.1257 | 0.1133 | 0.1033 | 0.0834 | 0.0951 | 18:01 | 0.0796 | 0.0950 | 0.0850 | 0.0901 | 0.0748 | 0.0908 | 07:02 | 0.0752 | 0.0672 | 0.0711 | 0.0705 | 0.0801 | 0.0655 | 08:01 | 0.0736 | 0.0917 | 0.0925 | 0.0651 | 0.0791 | 0.0842 | 35:01 | 0.0643 | 0.0450 | 0.0642 | 0.0568 | 0.0872 | 0.0570 | 35:03 | 0.0549 | 0.0601 | 0.0451 | 0.0465 | 0.0367 | 0.0496 | 38:01 | 0.0438 | 0.0542 | 0.0468 | 0.0529 | 0.0324 | 0.0450 | 15:01 | 0.0416 | 0.0304 | 0.0382 | 0.0407 | 0.0543 | 0.0421 | 27:05 | 0.0397 | 0.0385 | 0.0364 | 0.0426 | 0.0343 | 0.0440 | 13:02 | 0.0346 | 0.0304 | 0.0347 | 0.0313 | 0.0329 | 0.0360 | ∑ | 0.6118 | 0.6382 | 0.6273 | 0.5998 | 0.5952 | 0.6093 |
| HLA-DRB1 | 16:01 | 0.1037 | 0.1031 | 0.0723 | 0.0931 | 0.1301 | 0.0923 | 03:01 | 0.1006 | 0.1168 | 0.1127 | 0.0989 | 0.1063 | 0.1052 | 01:01 | 0.0999 | 0.0809 | 0.0948 | 0.0955 | 0.1072 | 0.0980 | 15:01 | 0.0902 | 0.0943 | 0.0942 | 0.0823 | 0.0739 | 0.0866 | 07:01 | 0.0885 | 0.0774 | 0.0890 | 0.0989 | 0.0820 | 0.0996 | 11:01 | 0.0796 | 0.0708 | 0.0809 | 0.0916 | 0.0834 | 0.0821 | 11:04 | 0.0767 | 0.0842 | 0.0942 | 0.0788 | 0.0777 | 0.0773 | 13:01 | 0.0597 | 0.0754 | 0.0647 | 0.0544 | 0.0577 | 0.0594 | 13:02 | 0.0418 | 0.0539 | 0.0457 | 0.0426 | 0.0405 | 0.0346 | 08:01 | 0.0292 | 0.0258 | 0.0225 | 0.0289 | 0.0300 | 0.0285 | ∑ | 0.7699 | 0.7826 | 0.7710 | 0.7650 | 0.7888 | 0.7636 |
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Legend: ZG: Zagreb; DA: Dalmatia; I&P: Istria & Primorje; CC: Central Croatia; NC: North Croatia; EC: East Croatia; AF: allele frequency.
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