Research Article

Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation

Table 2

The frequency of the 10 most frequent HLA-A, -C, -B, and -DRB1 alleles in Zagreb and their respective frequencies in five different Croatian regions.

ZG ()DA ()I&P ()CC ()NC ()EC ()
AFAFAFAFAFAF

HLA-A
 02:010.29460.28300.26880.29330.31460.2818
 01:010.12890.14070.14000.11660.11680.1396
 03:010.11760.10050.10810.11560.10960.1018
 24:020.11490.11060.12430.11850.11490.1119
 11:010.06600.08390.07230.06220.07580.0765
 26:010.04960.04600.04680.05930.04190.0519
 32:010.04360.04730.03930.03970.04290.0418
 68:010.04110.04370.04860.03870.03670.0397
 25:010.02920.02740.02780.02890.02530.0312
 23:010.02520.01860.02140.02940.01670.0237
 ∑0.91070.90170.89740.90220.89520.8999

HLA-C
 04:010.15720.13540.14570.14550.16680.1428
 07:010.14880.16970.16880.14100.15060.1630
 12:030.11610.13770.12020.12190.08480.1244
 02:020.09310.08750.07860.10240.09580.0916
 06:020.08350.08090.09830.09310.07200.0924
 07:020.08030.07020.08090.07690.08770.0717
 01:020.04520.05970.04860.04800.04050.0461
 03:030.04160.03330.03820.04070.04530.0418
 05:010.04130.04150.03470.03820.04000.0424
 15:020.03730.04150.04570.03580.03290.0330
 ∑0.84440.85740.85970.84350.81640.8492

HLA-B
 51:010.10450.12570.11330.10330.08340.0951
 18:010.07960.09500.08500.09010.07480.0908
 07:020.07520.06720.07110.07050.08010.0655
 08:010.07360.09170.09250.06510.07910.0842
 35:010.06430.04500.06420.05680.08720.0570
 35:030.05490.06010.04510.04650.03670.0496
 38:010.04380.05420.04680.05290.03240.0450
 15:010.04160.03040.03820.04070.05430.0421
 27:050.03970.03850.03640.04260.03430.0440
 13:020.03460.03040.03470.03130.03290.0360
 ∑0.61180.63820.62730.59980.59520.6093

HLA-DRB1
 16:010.10370.10310.07230.09310.13010.0923
 03:010.10060.11680.11270.09890.10630.1052
 01:010.09990.08090.09480.09550.10720.0980
 15:010.09020.09430.09420.08230.07390.0866
 07:010.08850.07740.08900.09890.08200.0996
 11:010.07960.07080.08090.09160.08340.0821
 11:040.07670.08420.09420.07880.07770.0773
 13:010.05970.07540.06470.05440.05770.0594
 13:020.04180.05390.04570.04260.04050.0346
 08:010.02920.02580.02250.02890.03000.0285
 ∑0.76990.78260.77100.76500.78880.7636

Legend: ZG: Zagreb; DA: Dalmatia; I&P: Istria & Primorje; CC: Central Croatia; NC: North Croatia; EC: East Croatia; AF: allele frequency.