Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis

Figure 3

Ultrastructure of promastigote forms of L. (L.) infantum treated with IC₅₀ of lupeol (Lu) for 24 h: (a) parasites treated with lupeol lost the fusiform shape, displayed cell membrane protrusions (arrowhead) and areas of cytoplasm degradation (); (b) detail of the mitochondria and kinetoplast from parasites treated with Lu (×50K); (c) nucleus showing condensed and fragmented chromatin after Lu treatment (×50K).

(a)

(b)

(c)