Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis

Figure 4

Ultrastructure of promastigote forms of L. (L.) infantum treated with IC₅₀ of ursolic acid (UA) for 24 h: (a) parasite showing round shape morphology, with areas of cytoplasm degradation () and nucleus with condensed and peripheral chromatin; the kinetoplast was swollen, and a bleb was identified (arrowhead) (×30K); (b) parasite treated with UA displayed myelin-like figures (MF) (×25K); (c) blebbing in the cell membrane (arrowhead) of promastigote forms treated with UA (×80K).

(a)

(b)

(c)