Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis

Figure 8

Splenic and hepatic parasitism from hamsters infected with L. (L.) infantum and treated with triterpenes. Hamsters were infected with promastigote forms of L. (L.) infantum, and four weeks after infection, animals were intraperitoneally treated once daily during 10 days with 2.5 mg/kg of ursolic acid (UA), lupeol (Lu), or 5 mg/kg of amphotericin B (AmB). The splenic and hepatic parasitism was quantified by limiting-dilution assay; additionally, amastigote forms were stained by immunohistochemistry technique.