Research Article

Related Pentacyclic Triterpenes Have Immunomodulatory Activity in Chronic Experimental Visceral Leishmaniasis

Table 1

Leishmanicidal and cytotoxic activity and selective index of betulin (Be), lupeol (Lu), and ursolic acid (UA). Results are expressed by mean and standard error of triplicates from three different experiments.

CompoundIC50 (μM) promastigotesIC50 (μM) amastigotesCC50 (μM)SI promastigotesSI amastigotes

BeNA1.3NA
Lu≥240≥58.5≥13.4
UA5.314.0
Miltefosine6.62.7