Moesin Is a Novel Biomarker of Endothelial Injury in Sepsis

Figure 2

LPS increased the MSN expression and lung injury in mice. BALB/c mice were intraperitoneally injected with the indicated doses of LPS for two days, and their serum MSN and PCT levels were examined by ELISA. Their lung W/D ratios and BALF protein levels were measured. (a) H&E staining of lung tissue sections in different groups of mice (magnification ×100). (b) Lung injury scores. (c) Pulmonary edema in different groups of mice. (d) The lung W/D ratios in different groups of mice. (e) LPS increased p-MSN and MSN expression in lung tissues in different groups of mice, and the semiquantification for WB was shown in (f). Serum MSN (g) and PCT (h) levels in different groups of mice. (i) BALF protein concentrations in different groups of mice. The correlation between serum MSN and PCT (j), serum MSN and lung injury scores (k), serum MSN levels, and lung W/D ratios (l). NS: not significant; , , .

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