Research Article
HMSC-Derived Exosome Inhibited Th2 Cell Differentiation via Regulating miR-146a-5p/SERPINB2 Pathway
Figure 3
The differentiation of AR CD4+ cells into Th2 type was downregulated after co-culture with HMSC-exo. (a, b) qRT-PCR and western blot analysis were used to examine the relative mRNA and protein levels of SERPINB2, T-bet, and GATA-3 in AR CD4+ after coculture with GW4869-exo or HMSC-exo. vs. control, vs. control. (c) The AR CD4+ cells differentiated into Th2 type cells were deeply suppressed after co-cultured with HMSC-exo. vs. Th1.
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