HMSC-Derived Exosome Inhibited Th2 Cell Differentiation via Regulating miR-146a-5p/SERPINB2 Pathway

Figure 5

miR-146a-5p inhibited the transcription of SERPINB2 by binding on its 3UTR. (a) qRT-PCR was used to examine the relative levels of miR-146a-5p and SERPINB2 in 293T cells after coculture with miR-146a-5p miNC, mimic, and inhibitor. vs. miNC. (b) The protein level of SERPINB2 was examined in 293T cells after coculture with miR-146a-5p miNC, mimic, and inhibitor. (c) The wild type and mutant binding site in the 3UTR of SEEPINB2 for miR-146a-5p. (d) Dual-luciferase report vector was used to determine the relationship between miR-146a-5p and SERPINB2 in293T cells. vs. miNC.

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