circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression

Figure 2

circCOL1A1 promotes the proliferation, migration, and invasion of gastric cancer cells. (a, b) Loss-of-function experiments were performed by transfecting siRNAs targeting circCOL1A1 into AGS and BGS-823 cancer cells. (c, d) Gain-of-function experiments were carried out by transfecting circCOL1A1 expression plasmids in MKN-45 and SGC-7901. (e–h) CCK8 assays were performed to detect the influence of circCOL1A1 on proliferation in gastric cancer cells. (i) Migration assays were performed to detect the influence of circCOL1A1 silence on AGS migration. (j) Migration assays were performed to detect the influence of circCOL1A1 overexpression on MKN-45 migration. (k) Invasion assays were performed to detect the influence of circCOL1A1 silence on AGS invasion. (l) Invasion assays were performed to detect the influence of circCOL1A1 overexpression on MKN-45 invasion.

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