Association of the PINX1 Variant rs6984094, Which Lengthens Telomeres, with Systemic Lupus Erythematosus Susceptibility in Chinese Populations

Table 1

Association analysis of single nucleotide polymorphisms from telomere-related genes with susceptibility to systemic lupus erythematosus in Chinese populations.

Chr.	Gene	SNP	Position (hg19)	Minor allele	Discovery stage (490/493)			Replication stage (1003/815)
					MAF (case/control %)	value	OR (95% CI)	MAF (case/control %)	value	OR (95% CI)
20	RTEL1	rs2738783	62308612	T	45.2/40.7		1.2 (1.01-1.44)	43.0/41.5	0.366	1.06 (0.93-1.21)
20	RTEL1-TNFRSF6B	rs6062496	62329099	A	11.2/15.1		0.71 (0.54-0.92)	13.0/13.0	0.999	1.00 (0.82-1.22)
8	PINX1	rs10089869	10634324	T	3.4/5.3		0.63 (0.40-0.98)	2.8/2.8	0.944	1.01 (0.68-1.51)
8	PINX1	rs6984094	10645738	C	2.3/4		0.58 (0.35-0.98)	1.0/2.1		0.46 (0.26-0.81)
5	TERT	rs2853676	1288547	A	19/14.1		1.43 (1.12-1.81)	20.0/18.1	0.154	1.13 (0.96-1.34)
		rs7726159	1282319	A	44/42		1.09 (0.91-1.31)	46.6/41.7		1.22 (1.07-1.39)
12	BICD1	rs1798613	32277522	T	23.2/19.5		1.25 (1.00-1.55)	22.9/22.7	0.883	1.01 (0.87-1.18)