Neuroprotective Effect of Taurine against Cell Death, Glial Changes, and Neuronal Loss in the Cerebellum of Rats Exposed to Chronic-Recurrent Neuroinflammation Induced by LPS

Figure 1

(a) Schematic illustration of experimental protocol for the taurine (TAU) at doses of 30 or 100 mg/kg and chronically exposed to lipopolysaccharide (LPS) toxin (250 μg/kg, intraperitoneally) treatments of rats. First, the rats were acclimatized for 10 days. Then, the treatment with TAU occurred once a day through an intragastric tube (gavage) during days 0 until 28. The LPS toxin was administered on days 7, 14, 21, and 28. On day 29, the animals were euthanized for cerebellar acquisition. (b) Representation of the fields chosen for the acquisition of the images of the tissue sections. A total of 5 sections were used for each rat. The red squares point to the cerebellar cortex of the cerebellar leaflets. The yellow squares show the regions chosen for the arbor vitae. The blue squares show the areas where images of the medullary center of the cerebellum were obtained. The images were acquired in a magnification of 200x, objective lens 20x, and field area of 200,500.10 μm². (c) Representation of the layers of the cerebellar leaflets: I, molecular layer; II, Purkinje cell layer; III, granular layer; and IV, white matter.

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