Neuroprotective Effect of Taurine against Cell Death, Glial Changes, and Neuronal Loss in the Cerebellum of Rats Exposed to Chronic-Recurrent Neuroinflammation Induced by LPS

Figure 5

Neuroprotective effect of taurine (TAU, 30-100 mg/kg by gavage; vehicle saline) on cell apoptosis by the number of cleaved caspase-3 positive cells in the regions: (a) molecular layer, (b) Purkinje cell layer, (c) granular layer, (d) arbor vitae, and (e) medullary center in cerebellum of rats exposed to chronic-recurrent neuroinflammation induced by the LPS toxin (250 μg/kg, intraperitoneally; vehicle saline). (f) Representative image of the immunostaining obtained through the fluorescence of the selected fields (yellow bar: 100 μm). was considered to represent a significant difference. denotes a significant difference compared to the vehicle group (VE). # denotes a significant difference compared to the LPS group. Two-way ANOVA followed by Bonferroni’s post hoc. or # denotes a difference of ; or ## denotes a difference of . Data are expressed as of the mean (SEM), -5 per group.

(a)

(b)

(c)

(d)

(e)

(f)