Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis

Table 2

Univariate and multivariate Cox proportional hazards analyses of MGSDMB expression and OS for patients with ccRCC.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
T stage	539
T1 & T2	349	Reference
T3 & T4	190	3.228 (2.382-4.374)	<0.001	1.373 (0.605-3.117)	0.448
N stage	257
N0	241	Reference
N1	16	3.453 (1.832-6.508)	<0.001	1.426 (0.708-2.872)	0.321
M stage	506
M0	428	Reference
M1	78	4.389 (3.212-5.999)	<0.001	2.494 (1.475-4.217)	<0.001
Pathologic stage	536
Stage I & stage II	331	Reference
Stage III & stage IV	205	3.946 (2.872-5.423)	<0.001	1.468 (0.579-3.725)	0.419
Gender	539
Female	186	Reference
Male	353	0.930 (0.682-1.268)	0.648
Age	539
≤60	269	Reference
>60	270	1.765 (1.298-2.398)	<0.001	1.766 (1.152-2.707)	0.009
Histologic grade	531
G1 & G2	249	Reference
G3 & G4	282	2.702 (1.918-3.807)	<0.001	1.666 (1.003-2.768)	0.049
GSDMB	539
Low	270	Reference
High	269	1.957 (1.434-2.671)	<0.001	2.059 (1.303-3.255)	0.002

ccRCC: clear cell renal cell carcinoma.