Bifidobacterium Longum: Protection against Inflammatory Bowel Disease

Table 1

Effects of B. longum strains in modulating inflammation based on in vitro and ex vivo studies.

Strains	Dose	Cell	Effect	Ref.
B. longum CECT-7347	cells/mL	HT-29 cell	IL-8 ↓	[62]
B. longum Bif10 and Bif16	CFU/mL	RAW264.7 cell	TNF-α, IL-1β, IL-6 ↓; SCFA ↑	[59]
B. longum BB536	cells/mL	PIE cell	TNF-α↓	[60]
B. longum KACC 91563	, 10^7, 10^8 CFU/well	Splenocytes macrophages	TNF-α ↓, IgE ↓; IL-2, 4, 6, 10, IFN-γ ↓	[51]
B. longum R0033	100 : 1 for bacteria to cell ratio	HT-29 cell	TNF-α, IL-8 ↓	[61]
B. longum 5^1A	, 10^5 CFU/well	Keratinocyte fibroblast cell	IL-6, IL-8 ↓	[73]
B. longum BL05	, 10^5, 10^6 CFU/well	HT-29 cell; THP-1 cell	IL-10 ↑; IL-1β, IL-6 ↓	[67]
B. longum LC67	, 10^5 CFU/mL	KATO III cells	NF-κB ↓; IL-8 ↓	[41]
B. longum LC67	, 10^6 CFU/mL	Caco-2 cells	NF-κB ↓	[28, 74]