Neuroprotective Effects of Asparagus officinalis Stem Extract in Transgenic Mice Overexpressing Amyloid Precursor Protein

Figure 1

(a) Experimental design—scheme of animal groups’s description; (b) effects of saline and/or ETAS (200 mg/kg and 1000 mg/kg) on APP-overexpressed mice and WT mice (1000 mg/kg) on escape latency (acquisition phase) using the Morris Water Maze ( mice in each group). APP saline, APP-ETAS 200 and 1000 mg/kg; WT saline and WT-ETAS 1000 mg/kg at days 3–6 vs. day 1; APP-ETAS 1000 mg/kg at day 2 vs. day 1; APP-ETAS 200 mg/kg day 2 vs. day 1. ♦ APP saline; ■ APP-ETAS 200 mg/kg; ▲ APP-ETAS 1000 mg/kg; □ WT saline and ○WT-ETAS 1000 mg/kg; Sec: seconds.

(a)

(b)