Lipopolysaccharide-Induced Transcriptional Changes in LBP-Deficient Rat and Its Possible Implications for Liver Dysregulation during Sepsis

<div>A proposed model of the WT and LBP-deficient rats after LPS administration. The upregulation of Ifng, Cxcl10, Serpine1, and Lbp in WT rats triggers NF-κB signaling pathway-induced inflammation response at 6 h after LPS injection, while the PPAR signaling pathway plays a part in bacterial clearance via the formation of NET by highlighted genes of C5, Cyp4a1, and Eci1 at 24 h after LPS administration in SD rats and of Dhrs7b and Tysnd1 in the LBP-/- rats.</div>

Journal of Immunology Research

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Figure 4: Lipopolysaccharide-Induced Transcriptional Changes in LBP-Deficient Rat and Its Possible Implications for Liver Dysregulation during Sepsis 

Figure 4 | Lipopolysaccharide-Induced Transcriptional Changes in LBP-Deficient Rat and Its Possible Implications for Liver Dysregulation during Sepsis 