Transcriptome Analysis of Large to Giant Congenital Melanocytic Nevus Reveals Cell Cycle Arrest and Immune Evasion: Identifying Potential Targets for Treatment
Table 1
Clinical characteristics of samples for transcriptome analysis.
Samples
Patient number
Sex
Age at biopsy date
Tissue site or 6B classification
PAS (cm)
CMN type
Satellites
New satellites formed after birth
Abnormal enlargement of the lesions after birth
Tumor 1
1
M
7 years
Scalp
20-30 cm
Large L1
20-50
No
No
Tumor 2
2
M
4 years
Back and breast
40-60 cm
Giant G1
No satellites
No
No
Tumor 3
3
M
4 years
Face and scalp
30-40 cm
Large L2
<20
No
No
Tumor 4
4
F
7 years
Bathing trunk
40-60 cm
Giant G1
20-50
No
No
Tumor 5
Thigh satellites
15-20 cm
Tumor 6
5
M
8 years
Back
30-40 cm
Large L2
<20
No
No
Tumor 7
Back satellites
10-15 cm
6
M
1 years
Bolero and breast
>60 cm
Giant G2
>50
No
No
Tumor 8
Thigh satellites
5-10 cm
Tumor 9
7
F
12 years
Face and neck
20-30 cm
Large L1
No satellites
No
No
Tumor 10
8
F
12 years
Arm
20-30 cm
Large L1
No satellites
No
No
Tumor 11
9
F
5 years
Bolero
40-60 cm
Giant G1
20-50
No
No
Tumor 12
10
F
20 years
Face and scalp
30-40 cm
Large L2
20-50
No
No
Normal 1
1
M
7 years
Adjacent normal skin
NA
NA
NA
NA
NA
Normal 2
2
M
4 years
Adjacent normal skin
NA
NA
NA
NA
NA
Normal 3
3
M
4 years
Adjacent normal skin
NA
NA
NA
NA
NA
Normal 4
4
M
7 years
Adjacent normal skin
NA
NA
NA
NA
NA
Patient 6 only underwent satellite excision because of age limitation. M: male; F: female; PAS: projected adult size; CMN: congenital melanocytic nevi; NA: not applicable.
