Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6

Figure 3

Silencing RIPK4 restrains OC cell migration and invasion. (a) RT-PCR was performed to assess the expression of RIPK4 in OC and normal ovarian cells. (b) RIPK4 silencing was carried out by using siRNA in SKOV3 and OVCAR3 cells. Silencing RIPK4 in OC cells significantly decreased their migratory ability, as observed in a wound healing assay (c and d), and their invasive ability, as observed in a Transwell assay (e and f). Images of subcutaneous xenografts are shown, (g), and the tumour volumes of the SKOV3 subcutaneous xenografts in the RIPK4-silenced group and control group are shown (h). The data are shown as the , and statistical significance is indicated as follows: represents and represents (unpaired -test).

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