Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6

Figure 4

GSEA results. (a) GSEA identified the top ten pathways in the high RIPK4 expression group based on the TCGA dataset including data from 593 OC patients. (b and c) GSEA showed that the high RIPK4 expression group was associated with EMT. (d) Gene profiling of hallmarks is shown in the heatmaps generated by comparing the high RIPK4 expression group and the low RIPK4 expression group. (e) Western blot assay results demonstrated that the levels of proteins promoting the EMT pathway were decreased in SKOV3-sh-RIPK4 cell lines.

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