Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6

Figure 6

Functional model of the IL-6 involved in restraining EMT in OC progression after downregulation of RIPK4 expression. RIPK4-silenced OC cells hypoactivated IL-6 signalling. Less STAT3 was phosphorylated, and the expression of SOCS1/3 was reduced. Consequently, the RIPK4-based IL-6 network is a determinant of EMT in OC.