Knockdown of lncRNA CCAT1 Inhibits the Progression of Colorectal Cancer via hsa-miR-4679 Mediating the Downregulation of GNG10

Figure 1

Knockdown of lncRNA CCAT1 inhibited the progression of colorectal cancer progression. (a) Relative expression of CCAT1 in CRC and normal tissues. (b) Relative expression of CCAT1 in FHC, a human colon immortalized cell line, and HT-29 and HCT-116, two colorectal cancer cell lines. (c) Relative expression of CCAT1 in HT-29 and HCT-116 after knockdown of CCAT1. (d) EdU staining was performed to detect the proliferation ability after the knockdown of CCAT1. (e) The statistical result of (d). (f) WB was performed to detect the levels of proliferation markers. (g) Transwell migration and invasion assays were performed to access the migration and invasion abilities after the knockdown of CCAT1. (h) The statistical results of (g). (i) FACS was performed to analyze the apoptosis rate after the knockdown of CCAT1. (j) The statistical result of (i). and .

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